Gamma Xi Phi is an international nonprofit organization led by an Executive Director and governed by a National Board of Trustees. The fraternity is divided into five administrative regions which are led by Regional Program Directors. The regions are North Atlantic, South Atlantic, Southwest, Midwest, and Far West. Each region serves an area of the United States as well as several international locales.
| North Atlantic Region | South Atlantic Region | Midwest Region | Southwest Region | Far West Region |
| Connecticut, Delaware, District of Columbia, Maine, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, and Vermont; Bermuda; the Canadian Province of Quebec and all Provinces to the east; Europe, North Africa, and East Africa | Alabama, Florida, Georgia, Mississippi, North Carolina, South Carolina, Tennessee, Virginia, West Virginia, the Bahamas, the Caribbean, and West Africa. | Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Montana, Nebraska, North Dakota, Ohio, South Dakota, Wisconsin, Wyoming, the Canadian Provinces of Ontario, Manitoba, Saskatchewan, and the Nunavut Territory, and Southern Africa. | Arizona, Arkansas, Colorado, Louisiana, New Mexico, Oklahoma, Texas, Utah, Central America, and South America. | Alaska, California, Hawaii, Idaho, Nevada, Oregon, and Washington; the Canadian Provinces of British Columbia and Alberta; the Yukon Territory and the Northwest Territories; Asia, Australia, and Oceania. |
| Alpha Beta Gamma Delta Epsilon Mu Tau Upsilon Alpha Lambda Alpha Iota | Theta Iota Nu Pi Rho Sigma Phi Beta Lambda Beta Iota | Kappa Xi Omicron Gamma Lambda Gamma Iota | Lambda Delta Lambda Delta Iota | Epsilon Lambda Epsilon Iota |